Change of scaling-induced proinflammatory cytokine on the clinical efficacy of periodontitis treatment.
Identifieur interne : 000187 ( Main/Exploration ); précédent : 000186; suivant : 000188Change of scaling-induced proinflammatory cytokine on the clinical efficacy of periodontitis treatment.
Auteurs : Kou-Gi Shyu [Taïwan] ; Cheuk-Sing Choy [Taïwan] ; Daniel Chung-Lang Wang [Taïwan] ; Wei-Chen Huang [Taïwan] ; Shyuan-Yow Chen [Taïwan] ; Chien-Hsun Chen [Taïwan] ; Che-Tong Lin [Taïwan] ; Chao-Chien Chang [Taïwan] ; Yung-Kai Huang [Taïwan]Source :
- TheScientificWorldJournal [ 1537-744X ] ; 2015.
Descripteurs français
- KwdFr :
- Adulte (MeSH), Adulte d'âge moyen (MeSH), Aire sous la courbe (MeSH), Courbe ROC (MeSH), Cytokines (métabolisme), Démographie (MeSH), Facteurs de risque (MeSH), Femelle (MeSH), Humains (MeSH), Mâle (MeSH), Médiateurs de l'inflammation (métabolisme), Parodontite (métabolisme), Parodontite (thérapie), Résultat thérapeutique (MeSH), Salive (métabolisme), Sujet âgé (MeSH).
- MESH :
- métabolisme : Cytokines, Médiateurs de l'inflammation, Parodontite, Salive.
- thérapie : Parodontite.
- Adulte, Adulte d'âge moyen, Aire sous la courbe, Courbe ROC, Démographie, Facteurs de risque, Femelle, Humains, Mâle, Résultat thérapeutique, Sujet âgé.
English descriptors
- KwdEn :
- Adult (MeSH), Aged (MeSH), Area Under Curve (MeSH), Cytokines (metabolism), Demography (MeSH), Female (MeSH), Humans (MeSH), Inflammation Mediators (metabolism), Male (MeSH), Middle Aged (MeSH), Periodontitis (metabolism), Periodontitis (therapy), ROC Curve (MeSH), Risk Factors (MeSH), Saliva (metabolism), Treatment Outcome (MeSH).
- MESH :
- chemical , metabolism : Cytokines, Inflammation Mediators.
- metabolism : Periodontitis, Saliva.
- therapy : Periodontitis.
- Adult, Aged, Area Under Curve, Demography, Female, Humans, Male, Middle Aged, ROC Curve, Risk Factors, Treatment Outcome.
Abstract
Proinflammatory cytokines are key inflammatory mediators in periodontitis. This study aimed to investigate the relationship between proinflammatory cytokines in saliva and periodontal status. To investigate the usefulness of cytokines in the therapeutic approach for periodontal disease, the relationship between stimulated cytokine changes and the periodontitis treatment outcome was investigated in this study. Saliva was obtained from 22 patients diagnosed by dentists as having chronic periodontitis. The proinflammatory cytokine (interleukin-1α (IL-1α), interleukin-1β (IL-1β), interleukin-6 (IL-6), interleukin-8 (IL-8), tumor necrosis factor α (TNF-α), and tumor necrosis factor β (TNF-β)) levels were determined using a commercially available kit. The IL-1β and IL-6 levels increased, whereas the TNF-β levels decreased with the severity of periodontitis (4 mm pocket percentage). Poststimulation IL-1α, IL-6, and IL-8 levels were higher in patients who had an improved treatment outcome. The differences of IL-6 levels (cut point: 0.05 μg/g) yielded a sensitivity and specificity of 90.0% and 81.82%, respectively, for predicting the periodontitis treatment outcome. Among the proinflammatory cytokines, stimulated IL-6 was an excellent marker for predicting the periodontitis treatment outcome.
DOI: 10.1155/2015/289647
PubMed: 25884025
PubMed Central: PMC4390110
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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Graduate Institute of Clinical Medicine, Taipei Medical University, Taipei 110, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Division of Cardiology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei 111, Taiwan ; Graduate Institute of Clinical Medicine, Taipei Medical University, Taipei 110</wicri:regionArea><wicri:noRegion>Taipei 110</wicri:noRegion></affiliation></author><author><name sortKey="Choy, Cheuk Sing" sort="Choy, Cheuk Sing" uniqKey="Choy C" first="Cheuk-Sing" last="Choy">Cheuk-Sing Choy</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan ; Department of Emergency, Min-Sheng General Hospital, Taoyuan 330, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan ; Department of Emergency, Min-Sheng General Hospital, Taoyuan 330</wicri:regionArea><wicri:noRegion>Taoyuan 330</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Daniel Chung Lang" sort="Wang, Daniel Chung Lang" uniqKey="Wang D" first="Daniel Chung-Lang" last="Wang">Daniel Chung-Lang Wang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Obstetrics and Gynecology, Min-Sheng General Hospital, Taoyuan 330, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Obstetrics and Gynecology, Min-Sheng General Hospital, Taoyuan 330</wicri:regionArea><wicri:noRegion>Taoyuan 330</wicri:noRegion></affiliation></author><author><name sortKey="Huang, Wei Chen" sort="Huang, Wei Chen" uniqKey="Huang W" first="Wei-Chen" last="Huang">Wei-Chen Huang</name><affiliation wicri:level="1"><nlm:affiliation>Dental Department, Cathay General Hospital, Taipei 106, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Dental Department, Cathay General Hospital, Taipei 106</wicri:regionArea><wicri:noRegion>Taipei 106</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Shyuan Yow" sort="Chen, Shyuan Yow" uniqKey="Chen S" first="Shyuan-Yow" last="Chen">Shyuan-Yow Chen</name><affiliation wicri:level="1"><nlm:affiliation>Dental Department, Cathay General Hospital, Taipei 106, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Dental Department, Cathay General Hospital, Taipei 106</wicri:regionArea><wicri:noRegion>Taipei 106</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Chien Hsun" sort="Chen, Chien Hsun" uniqKey="Chen C" first="Chien-Hsun" last="Chen">Chien-Hsun Chen</name><affiliation wicri:level="1"><nlm:affiliation>Dental Department, Cathay General Hospital, Taipei 106, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Dental Department, Cathay General Hospital, Taipei 106</wicri:regionArea><wicri:noRegion>Taipei 106</wicri:noRegion></affiliation></author><author><name sortKey="Lin, Che Tong" sort="Lin, Che Tong" uniqKey="Lin C" first="Che-Tong" last="Lin">Che-Tong Lin</name><affiliation wicri:level="1"><nlm:affiliation>School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei 110, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei 110</wicri:regionArea><wicri:noRegion>Taipei 110</wicri:noRegion></affiliation></author><author><name sortKey="Chang, Chao Chien" sort="Chang, Chao Chien" uniqKey="Chang C" first="Chao-Chien" last="Chang">Chao-Chien Chang</name><affiliation wicri:level="1"><nlm:affiliation>Graduate Institute of Clinical Medicine, Taipei Medical University, Taipei 110, Taiwan ; Department of Cardiology, Cathay General Hospital, Taipei 106, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Graduate Institute of Clinical Medicine, Taipei Medical University, Taipei 110, Taiwan ; Department of Cardiology, Cathay General Hospital, Taipei 106</wicri:regionArea><wicri:noRegion>Taipei 106</wicri:noRegion></affiliation></author><author><name sortKey="Huang, Yung Kai" sort="Huang, Yung Kai" uniqKey="Huang Y" first="Yung-Kai" last="Huang">Yung-Kai Huang</name><affiliation wicri:level="1"><nlm:affiliation>School of Oral Hygiene, College of Oral Medicine, Taipei Medical University, Taipei 110, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>School of Oral Hygiene, College of Oral Medicine, Taipei Medical University, Taipei 110</wicri:regionArea><wicri:noRegion>Taipei 110</wicri:noRegion></affiliation></author></analytic><series><title level="j">TheScientificWorldJournal</title><idno type="eISSN">1537-744X</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult (MeSH)</term><term>Aged (MeSH)</term><term>Area Under Curve (MeSH)</term><term>Cytokines (metabolism)</term><term>Demography (MeSH)</term><term>Female (MeSH)</term><term>Humans (MeSH)</term><term>Inflammation Mediators (metabolism)</term><term>Male (MeSH)</term><term>Middle Aged (MeSH)</term><term>Periodontitis (metabolism)</term><term>Periodontitis (therapy)</term><term>ROC Curve (MeSH)</term><term>Risk Factors (MeSH)</term><term>Saliva (metabolism)</term><term>Treatment Outcome (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte (MeSH)</term><term>Adulte d'âge moyen (MeSH)</term><term>Aire sous la courbe (MeSH)</term><term>Courbe ROC (MeSH)</term><term>Cytokines (métabolisme)</term><term>Démographie (MeSH)</term><term>Facteurs de risque (MeSH)</term><term>Femelle (MeSH)</term><term>Humains (MeSH)</term><term>Mâle (MeSH)</term><term>Médiateurs de l'inflammation (métabolisme)</term><term>Parodontite (métabolisme)</term><term>Parodontite (thérapie)</term><term>Résultat thérapeutique (MeSH)</term><term>Salive (métabolisme)</term><term>Sujet âgé (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Cytokines</term><term>Inflammation Mediators</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Periodontitis</term><term>Saliva</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Cytokines</term><term>Médiateurs de l'inflammation</term><term>Parodontite</term><term>Salive</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Periodontitis</term></keywords><keywords scheme="MESH" qualifier="thérapie" xml:lang="fr"><term>Parodontite</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Area Under Curve</term><term>Demography</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>ROC Curve</term><term>Risk Factors</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Aire sous la courbe</term><term>Courbe ROC</term><term>Démographie</term><term>Facteurs de risque</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Résultat thérapeutique</term><term>Sujet âgé</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Proinflammatory cytokines are key inflammatory mediators in periodontitis. This study aimed to investigate the relationship between proinflammatory cytokines in saliva and periodontal status. To investigate the usefulness of cytokines in the therapeutic approach for periodontal disease, the relationship between stimulated cytokine changes and the periodontitis treatment outcome was investigated in this study. Saliva was obtained from 22 patients diagnosed by dentists as having chronic periodontitis. The proinflammatory cytokine (interleukin-1α (IL-1α), interleukin-1β (IL-1β), interleukin-6 (IL-6), interleukin-8 (IL-8), tumor necrosis factor α (TNF-α), and tumor necrosis factor β (TNF-β)) levels were determined using a commercially available kit. The IL-1β and IL-6 levels increased, whereas the TNF-β levels decreased with the severity of periodontitis (4 mm pocket percentage). Poststimulation IL-1α, IL-6, and IL-8 levels were higher in patients who had an improved treatment outcome. The differences of IL-6 levels (cut point: 0.05 μg/g) yielded a sensitivity and specificity of 90.0% and 81.82%, respectively, for predicting the periodontitis treatment outcome. Among the proinflammatory cytokines, stimulated IL-6 was an excellent marker for predicting the periodontitis treatment outcome. </div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25884025</PMID><DateCompleted><Year>2016</Year><Month>07</Month><Day>12</Day></DateCompleted><DateRevised><Year>2018</Year><Month>11</Month><Day>13</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1537-744X</ISSN><JournalIssue CitedMedium="Internet"><Volume>2015</Volume><PubDate><Year>2015</Year></PubDate></JournalIssue><Title>TheScientificWorldJournal</Title><ISOAbbreviation>ScientificWorldJournal</ISOAbbreviation></Journal><ArticleTitle>Change of scaling-induced proinflammatory cytokine on the clinical efficacy of periodontitis treatment.</ArticleTitle><Pagination><MedlinePgn>289647</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1155/2015/289647</ELocationID><Abstract><AbstractText>Proinflammatory cytokines are key inflammatory mediators in periodontitis. This study aimed to investigate the relationship between proinflammatory cytokines in saliva and periodontal status. To investigate the usefulness of cytokines in the therapeutic approach for periodontal disease, the relationship between stimulated cytokine changes and the periodontitis treatment outcome was investigated in this study. Saliva was obtained from 22 patients diagnosed by dentists as having chronic periodontitis. The proinflammatory cytokine (interleukin-1α (IL-1α), interleukin-1β (IL-1β), interleukin-6 (IL-6), interleukin-8 (IL-8), tumor necrosis factor α (TNF-α), and tumor necrosis factor β (TNF-β)) levels were determined using a commercially available kit. The IL-1β and IL-6 levels increased, whereas the TNF-β levels decreased with the severity of periodontitis (4 mm pocket percentage). Poststimulation IL-1α, IL-6, and IL-8 levels were higher in patients who had an improved treatment outcome. The differences of IL-6 levels (cut point: 0.05 μg/g) yielded a sensitivity and specificity of 90.0% and 81.82%, respectively, for predicting the periodontitis treatment outcome. Among the proinflammatory cytokines, stimulated IL-6 was an excellent marker for predicting the periodontitis treatment outcome. </AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Shyu</LastName><ForeName>Kou-Gi</ForeName><Initials>KG</Initials><AffiliationInfo><Affiliation>Division of Cardiology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei 111, Taiwan ; Graduate Institute of Clinical Medicine, Taipei Medical University, Taipei 110, Taiwan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Choy</LastName><ForeName>Cheuk-Sing</ForeName><Initials>CS</Initials><AffiliationInfo><Affiliation>Department of Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan ; Department of Emergency, Min-Sheng General Hospital, Taoyuan 330, Taiwan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Daniel Chung-Lang</ForeName><Initials>DC</Initials><AffiliationInfo><Affiliation>Department of Obstetrics and Gynecology, Min-Sheng General Hospital, Taoyuan 330, Taiwan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Huang</LastName><ForeName>Wei-Chen</ForeName><Initials>WC</Initials><AffiliationInfo><Affiliation>Dental Department, Cathay General Hospital, Taipei 106, Taiwan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Shyuan-Yow</ForeName><Initials>SY</Initials><Identifier Source="ORCID">0000-0002-1841-1049</Identifier><AffiliationInfo><Affiliation>Dental Department, Cathay General Hospital, Taipei 106, Taiwan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Chien-Hsun</ForeName><Initials>CH</Initials><AffiliationInfo><Affiliation>Dental Department, Cathay General Hospital, Taipei 106, Taiwan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lin</LastName><ForeName>Che-Tong</ForeName><Initials>CT</Initials><AffiliationInfo><Affiliation>School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei 110, Taiwan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chang</LastName><ForeName>Chao-Chien</ForeName><Initials>CC</Initials><AffiliationInfo><Affiliation>Graduate Institute of Clinical Medicine, Taipei Medical University, Taipei 110, Taiwan ; Department of Cardiology, Cathay General Hospital, Taipei 106, Taiwan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Huang</LastName><ForeName>Yung-Kai</ForeName><Initials>YK</Initials><Identifier Source="ORCID">0000-0002-4467-0300</Identifier><AffiliationInfo><Affiliation>School of Oral Hygiene, College of Oral Medicine, Taipei Medical University, Taipei 110, Taiwan.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>03</Month><Day>25</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>ScientificWorldJournal</MedlineTA><NlmUniqueID>101131163</NlmUniqueID><ISSNLinking>1537-744X</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D016207">Cytokines</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D018836">Inflammation Mediators</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019540" MajorTopicYN="N">Area Under Curve</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016207" MajorTopicYN="N">Cytokines</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003710" MajorTopicYN="N">Demography</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018836" MajorTopicYN="N">Inflammation Mediators</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010518" MajorTopicYN="N">Periodontitis</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName><QualifierName UI="Q000628" MajorTopicYN="Y">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012372" MajorTopicYN="N">ROC Curve</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012307" MajorTopicYN="N">Risk Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012463" MajorTopicYN="N">Saliva</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016896" MajorTopicYN="N">Treatment Outcome</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2014</Year><Month>10</Month><Day>03</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2015</Year><Month>02</Month><Day>17</Day></PubMedPubDate><PubMedPubDate 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sort="Chang, Chao Chien" uniqKey="Chang C" first="Chao-Chien" last="Chang">Chao-Chien Chang</name><name sortKey="Chen, Chien Hsun" sort="Chen, Chien Hsun" uniqKey="Chen C" first="Chien-Hsun" last="Chen">Chien-Hsun Chen</name><name sortKey="Chen, Shyuan Yow" sort="Chen, Shyuan Yow" uniqKey="Chen S" first="Shyuan-Yow" last="Chen">Shyuan-Yow Chen</name><name sortKey="Choy, Cheuk Sing" sort="Choy, Cheuk Sing" uniqKey="Choy C" first="Cheuk-Sing" last="Choy">Cheuk-Sing Choy</name><name sortKey="Huang, Wei Chen" sort="Huang, Wei Chen" uniqKey="Huang W" first="Wei-Chen" last="Huang">Wei-Chen Huang</name><name sortKey="Huang, Yung Kai" sort="Huang, Yung Kai" uniqKey="Huang Y" first="Yung-Kai" last="Huang">Yung-Kai Huang</name><name sortKey="Lin, Che Tong" sort="Lin, Che Tong" uniqKey="Lin C" first="Che-Tong" last="Lin">Che-Tong Lin</name><name sortKey="Wang, Daniel Chung Lang" sort="Wang, Daniel Chung Lang" uniqKey="Wang D" first="Daniel Chung-Lang" last="Wang">Daniel Chung-Lang 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